The African Breast Cancer Epidemiology Study (AFBRECANE)
The AFBRECANE study is a case-control study funded by the NIH Common Fund to explore the genomic and epidemiological risk factors of molecular subtypes of breast cancer in African women.
The project is supported by the National Human Genome Research Institute of the National Institutes of Health under Award Number U01HG009784.
Genetics and Ethics of Familial Breast Cancer
With increased level of education and reduction in stigmatization and discrimination, more breast cancer patients with positive family history are being identified.
In the course of this study, women with positive first-generation family history of breast cancer will be identified.Using family based approaches and novel analytic methods, we can detect associations with common and rare variants. Our study is able to combine next generation whole genome sequencing of selected affected participants with genotyping of unaffected participants.
NCI Confluence Study
The Confluence project will develop a large research resource by 2021 to uncover breast cancer genetics through genome-wide association studies (GWAS). The resource will include at least 300,000 breast cancer cases and 300,000 controls of different races/ethnicities. This will be accomplished by the confluence of existing GWAS and new genome-wide genotyping data to be generated through this project.